Overview
Two Sigma Ventures is a venture capital firm based in New York that invests in early-stage companies[3]. The firm focuses on data, computing, software and robotics sectors[3], and is listed among the top venture capital firms in New York investing across biotech, data, computing, software and robotics[2]. Two Sigma Ventures specializes in machine learning infrastructure and employs a quantitative approach to artificial intelligence investing[1]. The firm has backed notable companies, including Gro Intelligence's $85 million Series B round[1]. More information about Two Sigma Ventures can be found at its official website[4].
Investments
Osmo
A digital scent design company developing AI-powered olfaction technology
SecurityScorecard
Security ratings and third-party cyber risk management platform
RapidSOS
New York City-headquartered emergency-response company applying AI to fuse device, sensor, and caller data into actionable intelligence for 911 centers and first responders.
Enigma
Business data and entity-resolution knowledge graph for underwriting, onboarding and verification
Kasisto
New York company building conversational AI for banks and financial institutions.
Cylera
New York City-headquartered healthcare IoT security company using machine learning to fingerprint, monitor, and protect connected medical devices.
Spell
New York, NY-based MLOps company providing infrastructure to train, deploy and operationalize deep learning models at scale.
NewtonX
New York B2B market research company combining AI with a verified-expert knowledge marketplace
Highbeam
New York, NY-based company building an AI-powered financial command center and banking platform for consumer and e-commerce brands.
Isabl
Whole-genome and transcriptome analysis of cancer patients for treatment planning
NYC presence
- Listed among the top venture capital firms in NYC, investing in biotech, data, computing, software and robotics[2]Oct 27, 2025
AI investing
- Specializes in ML infrastructure and a quantitative approach to AI investing; backed Gro Intelligence's $85M Series B[1]Dec 19, 2025
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