Two Sigma Ventures is a venture capital firm based in New York that invests in early-stage companies[3]. The firm focuses on data, computing, software and robotics sectors[3], and is listed among the top venture capital firms in New York investing across biotech, data, computing, software and robotics[2]. Two Sigma Ventures specializes in machine learning infrastructure and employs a quantitative approach to artificial intelligence investing[1]. The firm has backed notable companies, including Gro Intelligence's $85 million Series B round[1]. More information about Two Sigma Ventures can be found at its official website[4].
Investments
Cylera
New York City-headquartered healthcare IoT security company using machine learning to fingerprint, monitor, and protect connected medical devices.
Enigma
Business data and entity-resolution knowledge graph for underwriting, onboarding and verification
Highbeam
New York, NY-based company building an AI-powered financial command center and banking platform for consumer and e-commerce brands.
Isabl
Whole-genome and transcriptome analysis of cancer patients for treatment planning
Kasisto
New York company building conversational AI for banks and financial institutions.
NewtonX
New York B2B market research company combining AI with a verified-expert knowledge marketplace
- COsmo
A digital scent design company developing AI-powered olfaction technology
RapidSOS
New York City-headquartered emergency-response company applying AI to fuse device, sensor, and caller data into actionable intelligence for 911 centers and first responders.
SecurityScorecard
Security ratings and third-party cyber risk management platform
Spell
New York, NY-based MLOps company providing infrastructure to train, deploy and operationalize deep learning models at scale.
NYC presence
- Listed among the top venture capital firms in NYC, investing in biotech, data, computing, software and robotics[2]Oct 27, 2025
AI investing
- Specializes in ML infrastructure and a quantitative approach to AI investing; backed Gro Intelligence's $85M Series B[1]Dec 19, 2025
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