Overview
Blake Mandell is co-founder and CEO of Transcend Therapeutics[1][3], a clinical-stage neuroscience company developing rapid-acting treatments for PTSD and other neuropsychiatric disorders[2]. Transcend's lead candidate, TSND-201 (methylone), demonstrated statistically significant and clinically-meaningful improvements in PTSD symptoms in a Phase 2 clinical trial and received FDA Breakthrough Therapy designation[2]. The company plans to begin an approval-directed Phase 3 program in 2026[2]. Mandell previously served as co-founder and president of Transcend from April 2021 to September 2022[4], and held positions at AlleyCorp[5], Pace Capital[6], and The Boston Consulting Group[7]. Mandell holds a Bachelor of Arts in Mathematics and Contemplative Studies from Brown University[11] and a Master of Arts in Economics from Yenching Academy of Peking University[12].
Profile introduction
Blake is cofounder and CEO of Transcend Therapeutics, a clinical-stage, neuroscience-focused company developing rapid-acting treatments for PTSD and other neuropsychiatric disorders. The company's lead candidate, TSND-201 (methylone) — a rapid-acting neuroplastogen — demonstrated statistically significant and clinically-meaningful rapid, robust, and durable improvements in PTSD symptoms in a Phase 2 clinical trial. TSND-201 recently received FDA Breakthrough Therapy designation for the treatment of PTSD. Transcend plans to begin an approval-directed Phase 3 program in 2026. Blake was named t…
Career history
- Co-Founder and CEOSep 2022 to presentTranscend Therapeutics
- Co-Founder and PresidentApr 2021 to Sep 2022Transcend Therapeutics
- AssociateJul 2020 to Jul 2021AlleyCorp
- AssociateNov 2019 to Jun 2020Pace Capital
- Associate ConsultantJul 2018 to Nov 2019The Boston Consulting Group (BCG)
- Research Assistant, Embodied Neuroscience LabFeb 2015 to May 2017Brown University
- VP Sales and Co-FounderOct 2013 to May 2014get2kno, Inc
- Co-Founder, COOJun 2013 to Nov 2013Stash Storage (Peer-to-Peer Physical Storage Startup)
Education
Bachelor of Arts - BA, Mathematics and Contemplative Studies (double major)Brown University
- Master of Arts - MA, EconomicsYenching Academy of Peking University
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