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Aaron DeLoughery

Venture Partner at Flex Capital

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Overview

Aaron DeLoughery is a Venture Partner at Flex Capital [1][3]. DeLoughery spent six years at Mammoth Biosciences as an early member of the platform team, progressing through roles as Scientist, Senior Scientist, and Principal Scientist between May 2020 and February 2026 [4][5][6]. During this tenure, DeLoughery helped build the company's CRISPR nuclease discovery pipeline and discovered NanoCas, an ultracompact nuclease that enabled the first AAV-delivered muscle editing in non-human primates, while also managing scientists and collaborating across computational and translational teams [2]. Prior to Mammoth Biosciences, DeLoughery worked as a Scientist in Strain Engineering at Intrexon Corporation [7]. DeLoughery completed a Ph.D. in Molecular and Cellular Biology at Harvard University [10] and holds a B.S. in Biology with a Certificate in Liberal Arts and Management from Indiana University Bloomington [11].

Profile introduction
Source excerptLinkedIn [2]

I spent six years at Mammoth Biosciences as an early member of the platform team, where I helped build our CRISPR nuclease discovery pipeline and discovered NanoCas – an ultracompact nuclease that enabled the first AAV-delivered muscle editing in non-human primates. Along the way, I've managed scientists, collaborated across computational and translational teams, and helped identify the key mutations behind Mammoth's first drug candidate. I now consult independently for biotech companies on nuclease discovery, protein engineering strategy, and platform biology. I'm also exploring how my scien…

Career history

  1. Venture PartnerAug 2026 to presentFlex Capital
  2. Principal ScientistMar 2022 to Feb 2026Mammoth Biosciences
  3. Senior ScientistFeb 2021 to Mar 2022Mammoth Biosciences
  4. ScientistMay 2020 to Feb 2021Mammoth Biosciences
  5. Scientist Strain EngineeringOct 2018 to Apr 2020Intrexon Corporation
  6. Postdoctoral ResearcherJul 2016 to Sep 2018Massachusetts Institute of Technology
  7. Ph.D. StudentAug 2009 to Jul 2016Harvard University

Education

  1. PhD, Molecular and Cellular Biology2009 - 2016Harvard University
  2. BS, Biology, Certificate, Liberal Arts and Management2005 - 2009Indiana University Bloomington

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